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GPLD1
This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane. Belongs to the GPLD1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.4.50; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Phospholipase; Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 6p22.3 |
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Cellular Component:
cytoplasm; extracellular matrix; extracellular region; extracellular space; intracellular membrane-bounded organelle
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Molecular Function:
glycosylphosphatidylinositol phospholipase D activity; phospholipase D activity; sodium channel regulator activity
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Biological Process:
C-terminal protein lipidation; cell migration involved in sprouting angiogenesis; cellular response to calcium ion; cellular response to cholesterol; cellular response to insulin stimulus; cellular response to pH; cellular response to triglyceride; cellular response to xenobiotic stimulus; chondrocyte differentiation; complement receptor mediated signaling pathway; GPI anchor release; hematopoietic stem cell migration; hematopoietic stem cell migration to bone marrow; insulin receptor signaling pathway; negative regulation of cell population proliferation; negative regulation of triglyceride catabolic process; ossification; phosphatidylcholine metabolic process; positive regulation of alkaline phosphatase activity; positive regulation of apoptotic process; positive regulation of endothelial cell migration; positive regulation of glucose metabolic process; positive regulation of high-density lipoprotein particle clearance; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of membrane protein ectodomain proteolysis; positive regulation of secretion; positive regulation of triglyceride biosynthetic process; regulation of cellular response to insulin stimulus; response to glucose; transepithelial transport
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Reference #:
P80108
(UniProtKB)
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Alt. Names/Synonyms: Glycoprotein phospholipase D; Glycosyl-phosphatidylinositol-specific phospholipase D; glycosylphosphatidylinositol specific phospholipase D1; glycosylphosphatidylinositol specific phospholipase D1, isoform 2; glycosylphosphatIdylinositol-specific phospholipase D; GPI-PLD; GPI-specific phospholipase D; GPIPLD; GPIPLDM; GPLD1; MGC22590; PHLD; Phosphatidylinositol-glycan-specific phospholipase D; phospholipase D, phosphatidylinositol-glycan-specific; PI-G PLD; PIGPLD; PIGPLD1; PLD
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Gene Symbols: GPLD1
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Molecular weight:
92,336 Da
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Basal Isoelectric point:
5.91
Predict pI for various phosphorylation states
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