GPLD1 This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane. Belongs to the GPLD1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Phospholipase; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 6p22.3
Cellular Component:  cytoplasm; extracellular matrix; extracellular region; extracellular space; intracellular membrane-bounded organelle
Molecular Function:  glycosylphosphatidylinositol phospholipase D activity; phospholipase D activity; sodium channel regulator activity
Biological Process:  C-terminal protein lipidation; cell migration involved in sprouting angiogenesis; cellular response to calcium ion; cellular response to cholesterol; cellular response to drug; cellular response to insulin stimulus; cellular response to pH; cellular response to triglyceride; chondrocyte differentiation; complement receptor mediated signaling pathway; GPI anchor release; hematopoietic stem cell migration; hematopoietic stem cell migration to bone marrow; insulin receptor signaling pathway; negative regulation of cell proliferation; negative regulation of triglyceride catabolic process; ossification; phosphatidylcholine metabolic process; positive regulation of alkaline phosphatase activity; positive regulation of apoptotic process; positive regulation of cytolysis; positive regulation of endothelial cell migration; positive regulation of glucose metabolic process; positive regulation of high-density lipoprotein particle clearance; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of membrane protein ectodomain proteolysis; positive regulation of secretion; positive regulation of triglyceride biosynthetic process; regulation of cellular response to insulin stimulus; response to glucose; transepithelial transport
Reference #:  P80108 (UniProtKB)
Alt. Names/Synonyms: Glycoprotein phospholipase D; Glycosyl-phosphatidylinositol-specific phospholipase D; glycosylphosphatidylinositol specific phospholipase D1; glycosylphosphatidylinositol specific phospholipase D1, isoform 2; glycosylphosphatIdylinositol-specific phospholipase D; GPI-PLD; GPI-specific phospholipase D; GPIPLD; GPIPLDM; GPLD1; MGC22590; PHLD; Phosphatidylinositol-glycan-specific phospholipase D; phospholipase D, phosphatidylinositol-glycan-specific; PI-G PLD; PIGPLD; PIGPLD1; PLD
Gene Symbols: GPLD1
Molecular weight: 92,336 Da
Basal Isoelectric point: 5.91  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein