NRXN3 Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. Belongs to the neurexin family. Expressed in the blood vessel walls (at protein level). Highly expressed in brain, lung, and pancreas; a lower level of expression is detectable in heart, placenta, liver, and kidney, whereas no expression can be observed in skeletal muscle. Isoform 4a is heart-specific. 7 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of mouse Ortholog: 12 D3|12 42.94 cM
Cellular Component:  GABA-ergic synapse; integral component of membrane; membrane; presynaptic membrane; protein-containing complex
Molecular Function:  calcium channel regulator activity; metal ion binding; protein binding
Biological Process:  angiogenesis; cell adhesion; chemical synaptic transmission; neurotransmitter secretion; regulation of synaptic vesicle exocytosis; synapse assembly
Reference #:  Q6P9K9 (UniProtKB)
Alt. Names/Synonyms: 4933401A11Rik; 6332407J11; 9330112C09Rik; D12Bwg0831e; neurexin 3; neurexin III; neurexin III alpha; neurexin III beta; Neurexin III-alpha; Neurexin-3; Neurexin-3-alpha; NRX3A; Nrxn3; Nrxn3 protein
Gene Symbols: Nrxn3
Molecular weight: 173,428 Da
Basal Isoelectric point: 5.8  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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NRXN3

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein