NRXN3 Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. Belongs to the neurexin family. Expressed in the blood vessel walls (at protein level). Highly expressed in brain, lung, and pancreas; a lower level of expression is detectable in heart, placenta, liver, and kidney, whereas no expression can be observed in skeletal muscle. Isoform 4a is heart-specific. 7 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 14q24.3-q31.1
Cellular Component:  integral component of plasma membrane; plasma membrane
Molecular Function:  cell adhesion molecule binding; metal ion binding; neuroligin family protein binding; signaling receptor activity
Biological Process:  adult behavior; axon guidance; learning; neuron cell-cell adhesion; social behavior; vocalization behavior
Reference #:  Q9Y4C0 (UniProtKB)
Alt. Names/Synonyms: C14orf60; KIAA0743; MGC176711; neurexin 3; neurexin III; Neurexin III-alpha; neurexin III-beta; Neurexin-3; Neurexin-3-alpha; neurexin-3-beta; NRX3A; NRXN3
Gene Symbols: NRXN3
Molecular weight: 180,599 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein