COPS3 Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Belongs to the CSN3 family. Widely expressed. Expressed at high level in heart and skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component:  COP9 signalosome; cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  protein binding
Biological Process:  in utero embryonic development; nucleotide-excision repair, DNA damage recognition; post-translational protein modification; protein deneddylation; response to light stimulus; signal transduction; transcription-coupled nucleotide-excision repair
Reference #:  Q9UNS2 (UniProtKB)
Alt. Names/Synonyms: COP9 complex subunit 3; COP9 constitutive photomorphogenic homolog subunit 3; COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis); COP9 signalosome complex subunit 3; COP9 signalosome subunit 3; COPS3; CSN3; JAB1-containing signalosome subunit 3; SGN3; Signalosome subunit 3
Gene Symbols: COPS3
Molecular weight: 47,873 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein