Aiolos a transcription factor of the ikaros C2H2-type zinc-finger protein family. Plays an important role in the regulation of lymphocyte differentiation. Deletions in Aiolos have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 11|11 D
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; identical protein binding; metal ion binding; nucleic acid binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription regulatory region DNA binding
Biological Process:  B cell activation; positive regulation of transcription by RNA polymerase II; regulation of apoptotic process; regulation of B cell differentiation; regulation of B cell proliferation; regulation of lymphocyte differentiation; response to bacterium
Reference #:  O08900 (UniProtKB)
Alt. Names/Synonyms: 5830411O07Rik; Aiolos; IKAROS family zinc finger 3; Ikaros family zinc finger protein 3; Ikzf3; OTTMUSP00000006848; RP23-355L10.12; Zfpn1a3; Zinc finger protein Aiolos; zinc finger protein, subfamily 1A, 3 (Aiolos); Znfn1a3
Gene Symbols: Ikzf3
Molecular weight: 57,967 Da
Basal Isoelectric point: 5.9  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Aiolos

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene