Aiolos Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. Belongs to the Ikaros C2H2-type zinc-finger protein family. Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus. 16 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 17q12-q21.1
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; histone deacetylase binding; identical protein binding; metal ion binding; promoter-specific chromatin binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding
Biological Process:  B cell differentiation; mesoderm development; positive regulation of transcription by RNA polymerase II; regulation of apoptotic process; regulation of B cell differentiation; regulation of B cell proliferation; regulation of lymphocyte differentiation; regulation of transcription by RNA polymerase II; response to bacterium; T cell differentiation
Disease: Immunodeficiency 84
Reference #:  Q9UKT9 (UniProtKB)
Alt. Names/Synonyms: AIO; AIOLOS; IKAROS family zinc finger 3; IKAROS family zinc finger 3 (Aiolos); Ikaros family zinc finger protein 3; IKZF3; zinc finger DNA binding protein Aiolos; Zinc finger protein Aiolos; zinc finger protein, subfamily 1A, 3 (Aiolos); ZNFN1A3
Gene Symbols: IKZF3
Molecular weight: 58,023 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Aiolos

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene