Aiolos a transcription factor of the ikaros C2H2-type zinc-finger protein family. Plays an important role in the regulation of lymphocyte differentiation. Deletions in Aiolos have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 17q12-q21.1
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding
Biological Process:  B cell activation; mesoderm development; regulation of apoptotic process; regulation of B cell differentiation; regulation of B cell proliferation; regulation of lymphocyte differentiation; regulation of transcription by RNA polymerase II; response to bacterium
Reference #:  Q9UKT9 (UniProtKB)
Alt. Names/Synonyms: AIO; AIOLOS; IKAROS family zinc finger 3 (Aiolos); Ikaros family zinc finger protein 3; IKZF3; Zinc finger protein Aiolos; zinc finger protein, subfamily 1A, 3 (Aiolos); ZNFN1A3
Gene Symbols: IKZF3
Molecular weight: 58,023 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene