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Aiolos
a transcription factor of the ikaros C2H2-type zinc-finger protein family. Plays an important role in the regulation of lymphocyte differentiation. Deletions in Aiolos have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor |
| Chromosomal Location of Human Ortholog: 17q12-q21.1 |
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Cellular Component:
cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane
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Molecular Function:
DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding
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Biological Process:
B cell activation; mesoderm development; regulation of apoptotic process; regulation of B cell differentiation; regulation of B cell proliferation; regulation of lymphocyte differentiation; regulation of transcription by RNA polymerase II; response to bacterium
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Reference #:
Q9UKT9
(UniProtKB)
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Alt. Names/Synonyms: AIO; AIOLOS; IKAROS family zinc finger 3 (Aiolos); Ikaros family zinc finger protein 3; IKZF3; Zinc finger protein Aiolos; zinc finger protein, subfamily 1A, 3 (Aiolos); ZNFN1A3
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Gene Symbols: IKZF3
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Molecular weight:
58,023 Da
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Basal Isoelectric point:
6.11
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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