PARP4 Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Widely expressed; the highest levels are in the kidney; also detected in heart, placenta, lung, liver, skeletal muscle, spleen, leukocytes and pancreas. Note: This description may include information from UniProtKB.
Protein type: EC; Transferase
Chromosomal Location of Human Ortholog: 13q12.12
Cellular Component:  cytoplasm; cytosol; nucleus; ribonucleoprotein complex; spindle microtubule
Molecular Function:  DNA binding; enzyme binding; NAD+ ADP-ribosyltransferase activity; protein ADP-ribosylase activity; protein binding
Biological Process:  cell death; cellular protein modification process; cellular response to DNA damage stimulus; DNA repair; inflammatory response; protein ADP-ribosylation; regulation of telomerase activity; response to drug
Reference #:  Q9UKK3 (UniProtKB)
Alt. Names/Synonyms: 193 kDa vault protein; ADP-ribosyltransferase (NAD+; ADP-ribosyltransferase diphtheria toxin-like 4; ADPRTL1; ARTD4; H5 proline-rich; I-alpha-I-related; KIAA0177; p193; PARP-4; PARP-related; PARP-related/IalphaI-related H5/proline-rich; PARP4; PARPL; PH5P; poly (ADP-ribose) polymerase family, member 4; poly (ADP-ribose) polymerase)-like 1; Poly [ADP-ribose] polymerase 4; poly(ADP-ribose) polymerase family member 4; poly(ADP-ribose) synthetase; poly(ADP-ribosyl)transferase-like 1; Protein mono-ADP-ribosyltransferase PARP4; Vault poly(ADP-ribose) polymerase; vault protein, 193-kDa; VAULT3; von Willebrand factor A domain containing 5C; VPARP; VWA5C
Gene Symbols: PARP4
Molecular weight: 192,595 Da
Basal Isoelectric point: 5.43  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein