SLC25A13 Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle. Belongs to the mitochondrial carrier (TC 2.A.29) family. High levels in liver and low levels in kidney, pancreas, placenta, heart and brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 7q21.3
Cellular Component:  integral component of plasma membrane; mitochondrial inner membrane; mitochondrion
Molecular Function:  calcium ion binding; identical protein binding; L-aspartate transmembrane transporter activity; L-glutamate transmembrane transporter activity
Biological Process:  aspartate transmembrane transport; ATP biosynthetic process; cellular respiration; gluconeogenesis; L-aspartate transmembrane transport; L-glutamate transmembrane transport; malate-aspartate shuttle; mitochondrial transport; response to calcium ion
Disease: Citrullinemia, Type Ii, Adult-onset; Citrullinemia, Type Ii, Neonatal-onset
Reference #:  Q9UJS0 (UniProtKB)
Alt. Names/Synonyms: ARALAR2; Calcium-binding mitochondrial carrier protein Aralar2; Citrin; CMC2; CTLN2; Mitochondrial aspartate glutamate carrier 2; SLC25A13; Solute carrier family 25 member 13; solute carrier family 25, member 13; solute carrier family 25, member 13 (citrin)
Gene Symbols: SLC25A13
Molecular weight: 74,176 Da
Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene