FLRT3
Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina. Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members. Promotes neurite outgrowth (in vitro). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development. Expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart. Note: This description may include information from UniProtKB.
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Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. |
Chromosomal Location of mouse Ortholog: 2|2 F3 |
Cellular Component:
anchoring junction; axon terminus; axonal growth cone; cell junction; cell projection; cell-cell junction; cytosol; endoplasmic reticulum; extracellular region; extracellular space; focal adhesion; glutamatergic synapse; membrane; plasma membrane; postsynaptic density; postsynaptic membrane; synaptic membrane
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Molecular Function:
chemorepellent activity; fibroblast growth factor receptor binding; protein binding; protein homodimerization activity
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Biological Process:
axon guidance; cell adhesion; cell-cell adhesion via plasma-membrane adhesion molecules; embryonic morphogenesis; fibroblast growth factor receptor signaling pathway; head development; heart development; multicellular organism development; neuron projection development; neuron projection extension; positive regulation of synapse assembly; proepicardium cell migration involved in pericardium morphogenesis; response to axon injury; synapse assembly; synapse organization; synaptic membrane adhesion
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Reference #:
Q8BGT1
(UniProtKB)
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Alt. Names/Synonyms: 5530600M07Rik; C430047I10Rik; fibronectin leucine rich transmembrane protein 3; Flrt3; Kiaa1469; Leucine-rich repeat transmembrane protein FLRT3; mKIAA1469; OTTMUSP00000016617; OTTMUSP00000016618
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Gene Symbols: Flrt3
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Molecular weight:
72,879 Da
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Basal Isoelectric point:
8.31
Predict pI for various phosphorylation states
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