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CELSR1
Receptor that may have an important role in cell/cell signaling during nervous system formation. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of mouse Ortholog: 15 E2|15 40.42 cM |
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Cellular Component:
membrane; nucleoplasm; plasma membrane
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Molecular Function:
calcium ion binding; G protein-coupled receptor activity; protein binding; transmembrane signaling receptor activity
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Biological Process:
anterior/posterior pattern specification; apical protein localization; cell adhesion; cell surface receptor signaling pathway; cell-cell adhesion; establishment of body hair planar orientation; establishment of planar polarity; establishment of planar polarity of embryonic epithelium; G protein-coupled receptor signaling pathway; hair follicle development; homophilic cell adhesion via plasma membrane adhesion molecules; inner ear morphogenesis; lateral sprouting involved in lung morphogenesis; locomotory behavior; motor neuron migration; multicellular organism development; neural tube closure; orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis; planar cell polarity pathway involved in neural tube closure; planar dichotomous subdivision of terminal units involved in lung branching morphogenesis; protein localization involved in establishment of planar polarity; regulation of actin cytoskeleton organization; Rho protein signal transduction; signal transduction; wound healing
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Reference #:
O35161
(UniProtKB)
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Alt. Names/Synonyms: Adgr; Adgrc1; Cadherin EGF LAG seven-pass G-type receptor 1; cadherin, EGF LAG seven-pass G-type receptor 1; cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila); CELR1; Celsr1; crash; Crsh; Scy; seven-pass transmembrane receptor
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Gene Symbols: Celsr1
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Molecular weight:
330,471 Da
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Basal Isoelectric point:
5.57
Predict pI for various phosphorylation states
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