CELSR1 Receptor that may have an important role in cell/cell signaling during nervous system formation. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of mouse Ortholog: 15 E2|15 40.42 cM
Cellular Component:  membrane; nucleoplasm; plasma membrane
Molecular Function:  calcium ion binding; G protein-coupled receptor activity; protein binding; transmembrane signaling receptor activity
Biological Process:  anterior/posterior pattern specification; apical protein localization; cell adhesion; cell surface receptor signaling pathway; cell-cell adhesion; establishment of body hair planar orientation; establishment of planar polarity; establishment of planar polarity of embryonic epithelium; G protein-coupled receptor signaling pathway; hair follicle development; homophilic cell adhesion via plasma membrane adhesion molecules; inner ear morphogenesis; lateral sprouting involved in lung morphogenesis; locomotory behavior; motor neuron migration; multicellular organism development; neural tube closure; orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis; planar cell polarity pathway involved in neural tube closure; planar dichotomous subdivision of terminal units involved in lung branching morphogenesis; protein localization involved in establishment of planar polarity; regulation of actin cytoskeleton organization; Rho protein signal transduction; signal transduction; wound healing
Reference #:  O35161 (UniProtKB)
Alt. Names/Synonyms: Adgr; Adgrc1; Cadherin EGF LAG seven-pass G-type receptor 1; cadherin, EGF LAG seven-pass G-type receptor 1; cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila); CELR1; Celsr1; crash; Crsh; Scy; seven-pass transmembrane receptor
Gene Symbols: Celsr1
Molecular weight: 330,471 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
Select Structure to View Below

CELSR1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene