DPP3 Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin. Also cleaves Arg-Arg-beta-naphthylamide (in vitro). Belongs to the peptidase M49 family. Detected in placenta (at protein level) (PubMed:3233187). Detected in erythrocytes (at protein level) (PubMed:1515063). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.14.4; Protease
Chromosomal Location of Human Ortholog: 19|19 A
Cellular Component:  cytoplasm; cytosol; nuclear speck; plasma membrane
Molecular Function:  aminopeptidase activity; dipeptidyl-peptidase activity; hydrolase activity; metal ion binding; metallopeptidase activity; peptidase activity; zinc ion binding
Biological Process:  proteolysis
Reference #:  Q99KK7 (UniProtKB)
Alt. Names/Synonyms: 4930533O14Rik; C86324; Dipeptidyl aminopeptidase III; Dipeptidyl arylamidase III; Dipeptidyl peptidase 3; Dipeptidyl peptidase III; dipeptidyl-peptidase 3; dipeptidyl-peptidase III; dipeptidylpeptidase 3; dipeptidylpeptidase III; DPP III; Dpp3; Enkephalinase B
Gene Symbols: Dpp3
Molecular weight: 82,898 Da
Basal Isoelectric point: 5.26  Predict pI for various phosphorylation states
Select Structure to View Below

DPP3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene