TXNRD2 Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis. Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614, levels are low. High expression is observed in the adrenal cortex (PubMed:24601690). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Mitochondrial; Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine; Oxidoreductase
Chromosomal Location of Human Ortholog: 16 A3|16 11.41 cM
Cellular Component:  axon; cytoplasm; cytosol; dendrite; mitochondrion; neuronal cell body
Molecular Function:  electron transfer activity; flavin adenine dinucleotide binding; oxidoreductase activity; oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor; protein binding; protein homodimerization activity; thioredoxin-disulfide reductase activity
Biological Process:  cell redox homeostasis; heart development; hemopoiesis; response to oxygen radical
Reference #:  Q9JLT4 (UniProtKB)
Alt. Names/Synonyms: AA118373; ESTM573010; TGR; thioredoxin reductase 2; Thioredoxin reductase 2, mitochondrial; Thioredoxin reductase TR3; TR beta; Tr3; Trxr2; Trxrd2; Txnrd2
Gene Symbols: Txnrd2
Molecular weight: 56,603 Da
Basal Isoelectric point: 8.72  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA