TXNRD2 Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis. Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614, levels are low. High expression is observed in the adrenal cortex (PubMed:24601690). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Mitochondrial; Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine; Oxidoreductase
Chromosomal Location of human Ortholog: 22q11.21
Cellular Component:  axon; cytoplasm; cytosol; dendrite; mitochondrial matrix; mitochondrion; neuronal cell body
Molecular Function:  flavin adenine dinucleotide binding; protein binding; protein homodimerization activity; protein-containing complex binding; thioredoxin-disulfide reductase (NADP) activity
Biological Process:  cell redox homeostasis; cellular oxidant detoxification; response to hyperoxia; response to oxygen radical; response to selenium ion; response to xenobiotic stimulus
Disease: Glucocorticoid Deficiency 5
Reference #:  Q9NNW7 (UniProtKB)
Alt. Names/Synonyms: GCCD5; KIAA1652; Selenoprotein Z; SelZ; thioredoxin reductase 2; Thioredoxin reductase 2, mitochondrial; thioredoxin reductase 3; thioredoxin reductase beta; Thioredoxin reductase TR3; TR; TR-beta; TR3; TRXR2; TXNRD2
Gene Symbols: TXNRD2
Molecular weight: 56,507 Da
Basal Isoelectric point: 7.24  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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