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GALNT9
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Does not glycosylate apomucin or SDC3. Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. Specifically expressed in brain. Not expressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte. In brain, it is expressed in cerebellum, frontal lobe, temporal lobe, putamen and spinal cord, weakly expressed in cerebral cortex. Not expressed in medulla and occipital pole. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase |
| Chromosomal Location of human Ortholog: 12q24.33 |
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Cellular Component:
Golgi apparatus; Golgi membrane
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Molecular Function:
carbohydrate binding; metal ion binding; polypeptide N-acetylgalactosaminyltransferase activity
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Biological Process:
O-glycan processing; protein O-linked glycosylation
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Reference #:
Q9HCQ5
(UniProtKB)
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Alt. Names/Synonyms: GalNAc transferase 9; GalNAc-T9; GALNACT9; GALNT9; GALT9; Polypeptide GalNAc transferase 9; Polypeptide N-acetylgalactosaminyltransferase 9; pp-GaNTase 9; Protein-UDP acetylgalactosaminyltransferase 9; UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase 9; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 9; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
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Gene Symbols: GALNT9
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Molecular weight:
68,359 Da
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Basal Isoelectric point:
8.73
Predict pI for various phosphorylation states
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| Select Structure to View Below |
GALNT9
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