ITPA Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.1.19; Hydrolase; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes
Chromosomal Location of Human Ortholog: 2 F1|2 63.24 cM
Cellular Component:  cytoplasm; cytosol
Molecular Function:  dITP diphosphatase activity; hydrolase activity; identical protein binding; metal ion binding; NADH pyrophosphatase activity; nucleoside-triphosphate diphosphatase activity; nucleotide binding; nucleotide diphosphatase activity
Biological Process:  chromosome organization; ITP catabolic process; nucleoside triphosphate catabolic process; nucleotide metabolic process
Reference #:  Q9D892 (UniProtKB)
Alt. Names/Synonyms: 2010016I08Rik; AU020102; Inosine triphosphatase; inosine triphosphatase (nucleoside triphosphate pyrophosphatase); Inosine triphosphate pyrophosphatase; Itp; Itpa; ITPase; nucleoside triphosphate pyrophosphatase; OTTMUSP00000016511
Gene Symbols: Itpa
Molecular weight: 21,897 Da
Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states
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ITPA

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene