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ITPA
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.6.1.19; Hydrolase; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes |
| Chromosomal Location of mouse Ortholog: 2 F1|2 63.24 cM |
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Cellular Component:
cytoplasm; cytosol; intracellular membrane-bounded organelle; nucleoplasm
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Molecular Function:
dITP diphosphatase activity; hydrolase activity; identical protein binding; metal ion binding; nucleoside triphosphate diphosphatase activity; nucleotide binding
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Biological Process:
chromosome organization; ITP catabolic process; nucleoside triphosphate catabolic process; nucleotide metabolic process
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Reference #:
Q9D892
(UniProtKB)
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Alt. Names/Synonyms: 2010016I08Rik; AU020102; Inosine triphosphatase; inosine triphosphatase (nucleoside triphosphate pyrophosphatase); Inosine triphosphate pyrophosphatase; Itp; Itpa; ITPase; Non-canonical purine NTP pyrophosphatase; Non-standard purine NTP pyrophosphatase; NTPase; nucleoside triphosphate pyrophosphatase; Nucleoside-triphosphate diphosphatase; Nucleoside-triphosphate pyrophosphatase; OTTMUSP00000016511
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Gene Symbols: Itpa
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Molecular weight:
21,897 Da
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Basal Isoelectric point:
5.6
Predict pI for various phosphorylation states
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