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NAA15
Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter. Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, urogenital system and upper gastrointestinal tract. Overexpressed in gastric cancer, in papillary thyroid carcinomas and in a Burkitt lymphoma cell line (Daudi). Specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Acetyltransferase |
| Chromosomal Location of mouse Ortholog: 3|3 C |
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Cellular Component:
cytoplasm; cytosol; intracellular membrane-bounded organelle; NatA complex; nuclear body; nucleus; transcription regulator complex
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Molecular Function:
acetyltransferase activity; N-acetyltransferase activity; protein binding; ribosome binding
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Biological Process:
angiogenesis; cell differentiation; multicellular organism development; N-terminal peptidyl-methionine acetylation; N-terminal protein amino acid acetylation; negative regulation of apoptotic process; positive regulation of DNA-templated transcription; protein stabilization
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Reference #:
Q80UM3
(UniProtKB)
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Alt. Names/Synonyms: 5730450D16Rik; 6330400I15; AST; ASTBDN; MGC29428; mNA; mNAT1; N(alpha)-acetyltransferase 15, NatA auxiliary subunit; N-alpha-acetyltransferase 15, NatA auxiliary subunit; N-terminal acetyltransferase 1; N-terminal aceyltransferase 1; Naa15; Narg1; Nat1; NMDA receptor-regulated gene 1; NMDA receptor-regulated protein 1; Protein tubedown-1; Tbdn-; Tbdn-1; tubedo; Tubedown
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Gene Symbols: Naa15
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Molecular weight:
100,961 Da
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Basal Isoelectric point:
7.68
Predict pI for various phosphorylation states
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