PCAF Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY, PLK4 and TBX5. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5. Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4. Also acetylates spermidine. (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Belongs to the acetyltransferase family. GCN5 subfamily. Ubiquitously expressed but most abundant in heart and skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 3p24.3
Cellular Component:  A band; actomyosin; Ada2/Gcn5/Ada3 transcription activator complex; centrosome; I band; kinetochore; nucleoplasm; nucleus; PCAF complex; protein-containing complex
Molecular Function:  acetyltransferase activity; chromatin binding; cyclin-dependent protein serine/threonine kinase inhibitor activity; diamine N-acetyltransferase activity; histone acetyltransferase activity; histone deacetylase binding; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor; peptide-lysine-N-acetyltransferase activity; protein binding; protein kinase binding; RNA polymerase II regulatory region sequence-specific DNA binding; transcription coactivator activity; transcription coregulator activity; transcription factor binding
Biological Process:  cell cycle arrest; cellular response to insulin stimulus; chromatin remodeling; heart development; histone H3 acetylation; histone H3-K9 acetylation; internal peptidyl-lysine acetylation; limb development; N-terminal peptidyl-lysine acetylation; negative regulation of cell proliferation; negative regulation of centriole replication; negative regulation of cyclin-dependent protein serine/threonine kinase activity; Notch signaling pathway; peptidyl-lysine acetylation; positive regulation of gene expression, epigenetic; positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter; positive regulation of Notch signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of transcription of Notch receptor target; protein acetylation; protein deubiquitination; regulation of megakaryocyte differentiation; regulation of protein ADP-ribosylation; rhythmic process; transcription initiation from RNA polymerase II promoter; viral process
Reference #:  Q92831 (UniProtKB)
Alt. Names/Synonyms: CAF; CREBBP-associated factor; Histone acetylase PCAF; Histone acetyltransferase KAT2B; Histone acetyltransferase PCAF; K(lysine) acetyltransferase 2B; KAT2B; Lysine acetyltransferase 2B; P; P/CAF; P300/CBP-associated factor; PCAF; Spermidine acetyltransferase KAT2B
Gene Symbols: KAT2B
Molecular weight: 93,013 Da
Basal Isoelectric point: 9.16  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint  |  NF-kB Signaling  |  Protein Acetylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  InnateDB