ARID1B Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Binds DNA non-specifically. Widely expressed with high levels in heart, skeletal muscle and kidney. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 6q25.3
Cellular Component:  cytosol; nBAF complex; nucleoplasm; plasma membrane; SWI/SNF complex
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; transcription coactivator activity
Biological Process:  cellular response to angiotensin; chromatin remodeling; chromatin-mediated maintenance of transcription; dendritic cell dendrite assembly; dendritic spine development; neuron-neuron synaptic transmission; regulation of transcription by RNA polymerase II; response to ischemia
Disease: Coffin-siris Syndrome 1
Reference #:  Q8NFD5 (UniProtKB)
Alt. Names/Synonyms: 6A3-5; ARI1B; ARID domain-containing protein 1B; ARID1B; AT rich interactive domain 1B (SWI1-like); AT-rich interactive domain-containing protein 1B; BAF250B; BRG1-associated factor 250b; BRG1-binding protein ELD/OSA1; BRG1-binding protein hELD/OSA1; BRIGHT; DAN15; Eld (eyelid)/Osa protein; ELD/OSA1; hOsa2; KIAA1235; Osa homolog 2; OSA2; p250R
Gene Symbols: ARID1B
Molecular weight: 236,123 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein