|
ARID1B
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Binds DNA non-specifically. Widely expressed with high levels in heart, skeletal muscle and kidney. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: DNA-binding; Nuclear receptor co-regulator |
| Chromosomal Location of human Ortholog: 6q25.3 |
|
Cellular Component:
bBAF complex; brahma complex; chromatin; cytosol; nBAF complex; npBAF complex; nucleoplasm; plasma membrane; SWI/SNF complex
|
|
Molecular Function:
DNA binding; nucleosome binding; protein binding; transcription coactivator activity
|
|
Biological Process:
cellular response to angiotensin; chromatin remodeling; nervous system development; positive regulation of cell differentiation; positive regulation of DNA-templated transcription; positive regulation of double-strand break repair; positive regulation of myoblast differentiation; positive regulation of T cell differentiation; regulation of G0 to G1 transition; regulation of G1/S transition of mitotic cell cycle; regulation of mitotic metaphase/anaphase transition; regulation of nucleotide-excision repair; regulation of transcription by RNA polymerase II; response to ischemia; transcription initiation-coupled chromatin remodeling
|
|
Disease: Coffin-siris Syndrome 1; Desbuquois Dysplasia 2
|
|
Reference #:
Q8NFD5
(UniProtKB)
|
|
Alt. Names/Synonyms: 6A3-5; ARI1B; ARID domain-containing protein 1B; ARID1B; AT rich interactive domain 1B (SWI1-like); AT-rich interaction domain 1B; AT-rich interactive domain-containing protein 1B; BAF250B; BRG1-associated factor 250b; BRG1-binding protein ELD/OSA1; BRG1-binding protein hELD/OSA1; BRIGHT; CSS1; DAN15; Eld (eyelid)/Osa protein; ELD/OSA1; hOsa2; KIAA1235; MRD12; Osa homolog 2; OSA2; p250R
|
|
Gene Symbols: ARID1B
|
|
Molecular weight:
243,943 Da
|
|
Basal Isoelectric point:
6.43
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
