PABPN1 Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation. Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding
Chromosomal Location of Human Ortholog: 14 C2|14 27.98 cM
Cellular Component:  cytoplasm; nuclear inclusion body; nucleus; ribonucleoprotein complex
Molecular Function:  nucleic acid binding; poly(A) binding; protein binding; protein self-association; RNA binding; RNA polymerase binding
Biological Process:  cellular response to lipopolysaccharide; MAPK cascade; mRNA polyadenylation; mRNA processing; poly(A)+ mRNA export from nucleus; positive regulation of polynucleotide adenylyltransferase activity
Reference #:  Q8CCS6 (UniProtKB)
Alt. Names/Synonyms: mPABII; Nuclear poly(A)-binding protein 1; Pab2; PABII; PABP-2; Pabp2; Pabp3; Pabpn1; poly(A) binding protein II; poly(A) binding protein, nuclear 1; Poly(A)-binding protein 2; Poly(A)-binding protein II; Polyadenylate-binding nuclear protein 1; Polyadenylate-binding protein 2
Gene Symbols: Pabpn1
Molecular weight: 32,297 Da
Basal Isoelectric point: 5.13  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PABPN1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene