SAS6
Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing centriolar markers. Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification. Note: This description may include information from UniProtKB.
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Protein type: Cell cycle regulation |
Chromosomal Location of human Ortholog: 1p21.2 |
Cellular Component:
centriole; centrosome; cytoplasm; deuterosome; procentriole replication complex
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Molecular Function:
protein binding
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Biological Process:
centriole replication; centrosome duplication; positive regulation of centriole replication; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of spindle assembly; regulation of mitotic spindle organization
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Disease: Microcephaly 14, Primary, Autosomal Recessive
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Reference #:
Q6UVJ0
(UniProtKB)
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Alt. Names/Synonyms: FLJ22097; HsSAS-6; MCPH14; MGC119440; SAS-6; SAS-6 centriolar assembly protein; SAS6; SASS6; spindle assembly 6 homolog (C. elegans); Spindle assembly abnormal protein 6 homolog
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Gene Symbols: SASS6
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Molecular weight:
74,397 Da
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Basal Isoelectric point:
7.26
Predict pI for various phosphorylation states
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