SAS6 Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing centriolar markers. Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 1p21.2
Cellular Component:  centriole; centrosome; cytosol; deuterosome; microtubule organizing center
Molecular Function:  protein binding
Biological Process:  centriole replication; centrosome duplication
Disease: Microcephaly 14, Primary, Autosomal Recessive
Reference #:  Q6UVJ0 (UniProtKB)
Alt. Names/Synonyms: FLJ22097; HsSAS-6; MGC119440; SAS-6; SAS6; SASS6; spindle assembly 6 homolog (C. elegans); Spindle assembly abnormal protein 6 homolog
Gene Symbols: SASS6
Molecular weight: 74,397 Da
Basal Isoelectric point: 7.26  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene