FHL1 iso1 May have an involvement in muscle development or hypertrophy. Isoform 1 is highly expressed in skeletal muscle and to a lesser extent in heart, placenta, ovary, prostate, testis, small intestine, colon and spleen. Expression is barely detectable in brain, lung, liver, kidney, pancreas, thymus and peripheral blood leukocytes. Isoform 2 is expressed in brain, skeletal muscle and to a lesser extent in heart, colon, prostate and small intestine. Isoform 3 is expressed in testis, heart and skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation
Chromosomal Location of Human Ortholog: Xq26.3
Cellular Component:  cytoplasm; cytosol; nucleus; plasma membrane
Molecular Function:  ion channel binding; metal ion binding; protein binding
Biological Process:  animal organ morphogenesis; cell differentiation; muscle organ development; negative regulation of cell growth; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of G2/M transition of mitotic cell cycle; positive regulation of potassium ion transport; regulation of membrane depolarization; regulation of potassium ion transmembrane transporter activity
Disease: Myopathy, Reducing Body, X-linked, Childhood-onset; Myopathy, Reducing Body, X-linked, Early-onset, Severe; Myopathy, X-linked, With Postural Muscle Atrophy; Scapuloperoneal Myopathy, X-linked Dominant; Uruguay Faciocardiomusculoskeletal Syndrome
Reference #:  Q13642-1 (UniProtKB)
Alt. Names/Synonyms: FCMSU; FHL-1; FHL1; FHL1 iso1; FHL1A; FHL1B; FLH1A; four and a half LIM domains 1; Four and a half LIM domains protein 1; four-and-a-half Lin11, Isl-1 and Mec-3 domains 1; KYOT; LIM protein SLIMMER; MGC111107; RBMX1A; RBMX1B; Skeletal muscle LIM-protein 1; skeletal muscle LIM-protein1; SLIM; SLIM-1; SLIM1; SLIMMER; XMPMA
Gene Symbols: FHL1
Molecular weight: 31,895 Da
Basal Isoelectric point: 8.72  Predict pI for various phosphorylation states
Select Structure to View Below

FHL1 iso1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene