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NMI
May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5. Belongs to the NMI family. Expressed in all adult and fetal tissues except brain and skin. More abundant in fetal tissues especially liver. Note: This description may include information from UniProtKB.
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| Protein type: Transcription, coactivator/corepressor |
| Chromosomal Location of Human Ortholog: 2|2 C1.1 |
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Cellular Component:
cytoplasm; cytosol; nucleoplasm
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Molecular Function:
identical protein binding; protein binding; transcription coregulator activity
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Biological Process:
interferon-gamma-mediated signaling pathway; negative regulation of innate immune response; negative regulation of interferon-alpha biosynthetic process; negative regulation of interferon-beta biosynthetic process; negative regulation of type I interferon production; positive regulation of protein K48-linked ubiquitination; transcription by RNA polymerase II
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Reference #:
O35309
(UniProtKB)
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Alt. Names/Synonyms: N-mcy (and STAT) interactor; N-myc (and STAT) interactor; N-myc and STAT interactor; N-myc-interactor; Nmi; OTTMUSP00000013309; OTTMUSP00000013310
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Gene Symbols: Nmi
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Molecular weight:
35,236 Da
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Basal Isoelectric point:
4.98
Predict pI for various phosphorylation states
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