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NMI
May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5. Belongs to the NMI family. Expressed in all adult and fetal tissues except brain and skin. More abundant in fetal tissues especially liver. Note: This description may include information from UniProtKB.
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| Protein type: Transcription, coactivator/corepressor |
| Chromosomal Location of mouse Ortholog: 2|2 C1.1 |
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Cellular Component:
cytoplasm; cytosol; extracellular region; extracellular space; membrane; nucleoplasm; nucleus
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Molecular Function:
identical protein binding; protein binding
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Biological Process:
immune system process; innate immune response; macrophage activation involved in immune response; negative regulation of cell population proliferation; negative regulation of innate immune response; negative regulation of interferon-alpha production; negative regulation of interferon-beta production; negative regulation of NIK/NF-kappaB signaling; negative regulation of type I interferon production; positive regulation of inflammatory response; positive regulation of innate immune response; positive regulation of NIK/NF-kappaB signaling; positive regulation of protein K48-linked ubiquitination; protein K48-linked ubiquitination; response to virus; toll-like receptor 4 signaling pathway
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Reference #:
O35309
(UniProtKB)
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Alt. Names/Synonyms: N-mcy (and STAT) interactor; N-myc (and STAT) interactor; N-myc and STAT interactor; N-myc-interactor; Nmi; OTTMUSP00000013309; OTTMUSP00000013310
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Gene Symbols: Nmi
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Molecular weight:
35,236 Da
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Basal Isoelectric point:
4.98
Predict pI for various phosphorylation states
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