NMI
May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5. Belongs to the NMI family. Expressed in all adult and fetal tissues except brain and skin. More abundant in fetal tissues especially liver. Note: This description may include information from UniProtKB.
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Protein type: Transcription, coactivator/corepressor |
Chromosomal Location of human Ortholog: 2q23.3 |
Cellular Component:
cytoplasm; cytosol; extracellular space; membrane; nucleoplasm; nucleus
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Molecular Function:
identical protein binding; protein binding
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Biological Process:
innate immune response; macrophage activation involved in immune response; negative regulation of cell population proliferation; negative regulation of innate immune response; negative regulation of interferon-alpha production; negative regulation of interferon-beta production; negative regulation of NIK/NF-kappaB signaling; positive regulation of inflammatory response; positive regulation of innate immune response; positive regulation of NIK/NF-kappaB signaling; positive regulation of protein K48-linked ubiquitination; protein K48-linked ubiquitination; receptor signaling pathway via JAK-STAT; response to virus; toll-like receptor 4 signaling pathway
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Reference #:
Q13287
(UniProtKB)
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Alt. Names/Synonyms: N-myc (and STAT) interactor; N-myc and STAT interactor; N-myc interactor; N-myc-interactor; NMI
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Gene Symbols: NMI
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Molecular weight:
35,057 Da
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Basal Isoelectric point:
5.24
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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