OGDH 2-oxoglutarate dehydrogenase (E1) component of the 2-oxoglutarate dehydrogenase complex, which mediates the decarboxylation of alpha-ketoglutarate. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. Belongs to the alpha-ketoglutarate dehydrogenase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.2.4.2; Mitochondrial; Oxidoreductase
Chromosomal Location of human Ortholog: 7p13
Cellular Component:  mitochondrial matrix; mitochondrial membrane; mitochondrion; nucleus; oxoglutarate dehydrogenase complex
Molecular Function:  metal ion binding; oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamine pyrophosphate binding
Biological Process:  2-oxoglutarate metabolic process; generation of precursor metabolites and energy; glycolytic process; histone succinylation; lysine catabolic process; succinyl-CoA metabolic process; tricarboxylic acid cycle
Disease: Alpha-ketoglutarate Dehydrogenase Deficiency
Reference #:  Q02218 (UniProtKB)
Alt. Names/Synonyms: 2-oxoglutarate dehydrogenase complex component E1; 2-oxoglutarate dehydrogenase, mitochondrial; AKGDH; Alpha-ketoglutarate dehydrogenase; E1k; KGD1; ODO1; OGDC; OGDC-E1; OGDH; OGDH2; oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide); oxoglutarate decarboxylase; oxoglutarate dehydrogenase; oxoglutarate dehydrogenase (lipoamide); oxoglutarate dehydrogenase (succinyl-transferring); testicular tissue protein Li 131
Gene Symbols: OGDH
Molecular weight: 115,935 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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OGDH

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB