GPSM2 Plays an important role in mitotic spindle pole organization via its interaction with NUMA1. Required for cortical dynein-dynactin complex recruitment during metaphase. Plays a role in metaphase spindle orientation. Plays also an important role in asymmetric cell divisions. Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity. Belongs to the GPSM family. Ubiquitously expressed. Note: This description may include information from UniProtKB.
Protein type: G protein regulator, misc.
Chromosomal Location of Human Ortholog: 3|3 F3
Cellular Component:  apical part of cell; cell cortex; cell cortex region; centrosome; cytoplasm; cytoskeleton; cytosol; lateral cell cortex; membrane; mitotic spindle pole; plasma membrane; protein-containing complex
Molecular Function:  dynein complex binding; G-protein alpha-subunit binding; GDP-dissociation inhibitor activity; GTPase regulator activity; identical protein binding; nucleotide binding; protein binding; protein C-terminus binding; protein domain specific binding; protein self-association
Biological Process:  cell cycle; cell division; establishment of mitotic spindle orientation; lung epithelial cell differentiation; maintenance of centrosome location; mitotic spindle organization; positive regulation of protein localization to cell cortex; positive regulation of spindle assembly; Ran protein signal transduction; regulation of mitotic spindle organization
Reference #:  Q8VDU0 (UniProtKB)
Alt. Names/Synonyms: 6230410J09Rik; G-protein signalling modulator 2 (AGS3-like, C. elegans); G-protein-signaling modulator 2; Gpsm2; Lgn; LGN protein; Pins; Pins homolog; pins homolog (Drosophia)
Gene Symbols: Gpsm2
Molecular weight: 75,591 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene