coronin 7 F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology. Belongs to the WD repeat coronin family. Widely expressed. Expressed in the spleen, peripheral leukocytes, testes, brain, thymus and small intestine. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of human Ortholog: 16p13.3
Cellular Component:  cytoplasmic vesicle; cytosol; Golgi apparatus; Golgi membrane; membrane; trans-Golgi network
Molecular Function:  actin binding; actin filament binding; protein binding
Biological Process:  actin filament organization; actin filament polymerization; cell migration; establishment of cell polarity; Golgi organization; Golgi to endosome transport; positive regulation of hippo signaling; protein transport
Reference #:  P57737 (UniProtKB)
Alt. Names/Synonyms: 0610011B16Rik; 70 kDa WD repeat tumor rejection antigen homolog; CORO7; coronin 7; Coronin-7; Crn7; FLJ22021; FLJ44188; POD1
Gene Symbols: CORO7
Molecular weight: 100,605 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
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coronin 7

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein