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coronin 7
F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology. Belongs to the WD repeat coronin family. Widely expressed. Expressed in the spleen, peripheral leukocytes, testes, brain, thymus and small intestine. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Vesicle |
| Chromosomal Location of human Ortholog: 16p13.3 |
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Cellular Component:
cytoplasmic vesicle; cytosol; Golgi apparatus; Golgi membrane; membrane; trans-Golgi network
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Molecular Function:
actin binding; actin filament binding; protein binding
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Biological Process:
actin filament organization; actin filament polymerization; cell migration; establishment of cell polarity; Golgi organization; Golgi to endosome transport; positive regulation of hippo signaling; protein transport
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Reference #:
P57737
(UniProtKB)
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Alt. Names/Synonyms: 0610011B16Rik; 70 kDa WD repeat tumor rejection antigen homolog; CORO7; coronin 7; Coronin-7; Crn7; FLJ22021; FLJ44188; POD1
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Gene Symbols: CORO7
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Molecular weight:
100,605 Da
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Basal Isoelectric point:
5.51
Predict pI for various phosphorylation states
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