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USP11
Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex. Belongs to the peptidase C19 family. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease |
| Chromosomal Location of mouse Ortholog: X|X A1.3 |
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Cellular Component:
chromosome; cytoplasm; cytosol; nucleoplasm; nucleus
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Molecular Function:
cysteine-type deubiquitinase activity; cysteine-type endopeptidase activity; cysteine-type peptidase activity; hydrolase activity; peptidase activity; transcription corepressor binding
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Biological Process:
protein deubiquitination; proteolysis; ubiquitin-dependent protein catabolic process
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Reference #:
Q99K46
(UniProtKB)
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Alt. Names/Synonyms: 6230415D12Rik; Deubiquitinating enzyme 11; KIAA4085; MGC6649; mKIAA4085; Ubiquitin carboxyl-terminal hydrolase 11; ubiquitin specific peptidase 11; ubiquitin specific protease 11; Ubiquitin thioesterase 11; ubiquitin thiolesterase 11; Ubiquitin-specific-processing protease 11; UBP11; Usp11
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Gene Symbols: Usp11
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Molecular weight:
105,384 Da
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Basal Isoelectric point:
4.83
Predict pI for various phosphorylation states
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