USP11 Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex. Belongs to the peptidase C19 family. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: Xp11.3
Cellular Component:  chromosome; cytosol; nucleoplasm; nucleus
Molecular Function:  cysteine-type endopeptidase activity; protein binding; thiol-dependent ubiquitin-specific protease activity; thiol-dependent ubiquitinyl hydrolase activity
Biological Process:  protein deubiquitination; ubiquitin-dependent protein catabolic process
Reference #:  P51784 (UniProtKB)
Alt. Names/Synonyms: Deubiquitinating enzyme 11; Ubiquitin carboxyl-terminal hydrolase 11; ubiquitin carboxyl-terminal hydrolase, X-linked; ubiquitin specific peptidase 11; Ubiquitin thioesterase 11; ubiquitin thiolesterase 11; ubiquitin-specific processing protease 11; Ubiquitin-specific-processing protease 11; UBP11; UHX1; USP11
Gene Symbols: USP11
Molecular weight: 109,817 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
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USP11

Protein Structure Not Found.


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