LOX Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture. Belongs to the lysyl oxidase family. Heart, placenta, skeletal muscle, kidney, lung and pancreas. Note: This description may include information from UniProtKB.
Protein type: EC; Oxidoreductase; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 18 D1|18 28.22 cM
Cellular Component:  collagen trimer; extracellular matrix; extracellular region; extracellular space; nucleus
Molecular Function:  copper ion binding; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor; protein binding; protein-lysine 6-oxidase activity
Biological Process:  aorta development; ascending aorta development; blood vessel development; blood vessel morphogenesis; bone mineralization; cell chemotaxis; cellular response to chemokine; cellular response to organic substance; collagen fibril organization; connective tissue development; descending aorta development; DNA biosynthetic process; elastic fiber assembly; heart development; lung development; muscle cell cellular homeostasis; muscle fiber development; osteoblast differentiation; oxidation-reduction process; peptidyl-lysine oxidation; platelet-derived growth factor receptor-beta signaling pathway; protein kinase B signaling; protein oxidation; regulation of apoptotic process; regulation of bone development; regulation of gene expression; regulation of megakaryocyte differentiation; regulation of platelet-derived growth factor receptor-beta signaling pathway; regulation of protein phosphorylation; regulation of receptor binding; regulation of striated muscle tissue development; regulation of transforming growth factor beta receptor signaling pathway; response to hormone; response to steroid hormone; wound healing
Reference #:  P28301 (UniProtKB)
Alt. Names/Synonyms: AI893619; Lox; LYOX; Lysyl oxidase; Protein-lysine 6-oxidase; Protein-lysine 6-oxidase, long form; Protein-lysine 6-oxidase, short form; Ras excision protein; ras recision gene (rrg); Rrg; TSC-16; TSC-160
Gene Symbols: Lox
Molecular weight: 46,701 Da
Basal Isoelectric point: 8.73  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene