LOX Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture. Belongs to the lysyl oxidase family. Heart, placenta, skeletal muscle, kidney, lung and pancreas. Note: This description may include information from UniProtKB.
Protein type: EC; Oxidoreductase; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 5q23.1
Cellular Component:  collagen trimer; extracellular matrix; extracellular region; nucleus
Molecular Function:  copper ion binding; protein binding; protein-lysine 6-oxidase activity
Biological Process:  ascending aorta development; blood vessel morphogenesis; bone mineralization; cell chemotaxis; cellular protein modification process; cellular response to chemokine; collagen fibril organization; connective tissue development; descending aorta development; DNA biosynthetic process; elastic fiber assembly; extracellular matrix organization; heart development; lung development; muscle cell cellular homeostasis; muscle fiber development; osteoblast differentiation; platelet-derived growth factor receptor-beta signaling pathway; protein kinase B signaling; regulation of apoptotic process; regulation of bone development; regulation of gene expression; regulation of megakaryocyte differentiation; regulation of platelet-derived growth factor receptor-beta signaling pathway; regulation of protein phosphorylation; regulation of receptor binding; regulation of striated muscle tissue development; regulation of transforming growth factor beta receptor signaling pathway; response to drug; response to steroid hormone; wound healing
Disease: Aortic Aneurysm, Familial Thoracic 10
Reference #:  P28300 (UniProtKB)
Alt. Names/Synonyms: AAT10; LOX; LYOX; Lysyl oxidase; MGC105112; Protein-lysine 6-oxidase; Protein-lysine 6-oxidase, long form; Protein-lysine 6-oxidase, short form
Gene Symbols: LOX
Molecular weight: 46,944 Da
Basal Isoelectric point: 8.36  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene