CRHBP Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 5q13.3
Cellular Component:  axon terminus; dendrite; dense core granule; extracellular region; extracellular space; microtubule; multivesicular body; nucleus; perikaryon; secondary lysosome; secretory granule; varicosity
Molecular Function:  corticotropin-releasing hormone binding; peptide binding; protein binding
Biological Process:  behavioral response to ethanol; cellular response to calcium ion; cellular response to cAMP; cellular response to cocaine; cellular response to drug; cellular response to estradiol stimulus; cellular response to estrogen stimulus; cellular response to gonadotropin-releasing hormone; cellular response to potassium ion; cellular response to tumor necrosis factor; female pregnancy; hormone-mediated signaling pathway; inflammatory response; learning or memory; maternal aggressive behavior; negative regulation of corticotropin secretion; negative regulation of corticotropin-releasing hormone receptor activity; regulated exocytosis; regulation of cellular response to stress; regulation of corticotropin secretion; regulation of NMDA receptor activity; signal transduction; synaptic transmission, dopaminergic
Reference #:  P24387 (UniProtKB)
Alt. Names/Synonyms: corticotropin releasing hormone binding protein; corticotropin releasing hormone-binding protein; Corticotropin-releasing factor-binding protein; Corticotropin-releasing hormone-binding protein; CRF-binding protein; CRF-BP; CRFBP; CRH-BP; CRHBP
Gene Symbols: CRHBP
Molecular weight: 36,144 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene