NEB This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin. Muscle specific. Located in the thin filament of striated muscle. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 2q23.3
Cellular Component:  actin cytoskeleton; cytosol; Z disc
Molecular Function:  protein binding; structural constituent of muscle
Biological Process:  muscle filament sliding; muscle organ development; regulation of actin filament length; somatic muscle development
Disease: Nemaline Myopathy 2
Reference #:  P20929 (UniProtKB)
Alt. Names/Synonyms: DKFZp686C1456; FLJ11505; FLJ36536; FLJ39568; FLJ39584; NEB; NEB177D; NEBU; Nebulin; NEM2; nemaline myopathy type 2
Gene Symbols: NEB
Molecular weight: 772,914 Da
Basal Isoelectric point: 9.11  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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