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ADRA2B
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of human Ortholog: 2q11.2 |
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Cellular Component:
cell surface; cytosol; intracellular membrane-bounded organelle; plasma membrane
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Molecular Function:
alpha2-adrenergic receptor activity; epinephrine binding; protein binding
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Biological Process:
activation of protein kinase B activity; adenylate cyclase-activating adrenergic receptor signaling pathway; adrenergic receptor signaling pathway; angiogenesis; cell-cell signaling; female pregnancy; G protein-coupled receptor signaling pathway; MAPK cascade; negative regulation of epinephrine secretion; negative regulation of norepinephrine secretion; platelet activation; positive regulation of blood pressure; positive regulation of MAPK cascade; positive regulation of neuron differentiation; positive regulation of uterine smooth muscle contraction; receptor transactivation; regulation of vascular associated smooth muscle contraction
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Disease: Epilepsy, Familial Adult Myoclonic, 2
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Reference #:
P18089
(UniProtKB)
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Alt. Names/Synonyms: ADA2B; ADRA2B; ADRA2B adrenergic, alpha-2B-, receptor; ADRA2L1; ADRA2RL1; ADRARL1; adrenergic receptor alpha 2B; adrenergic, alpha-2B-, receptor; adrenoceptor alpha 2B; Alpha-2 adrenergic receptor subtype C2; alpha-2-adrenergic receptor-like 1; Alpha-2B adrenergic receptor; Alpha-2B adrenoceptor; Alpha-2B adrenoreceptor; alpha-2B-adrenergic receptor; Alpha-2BAR; ALPHA2BAR; FAME2; G-protein coupled receptor
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Gene Symbols: ADRA2B
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Molecular weight:
49,954 Da
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Basal Isoelectric point:
8.8
Predict pI for various phosphorylation states
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