CBR1 NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.1.1.184; EC 1.1.1.189; EC 1.1.1.197; Lipid Metabolism - arachidonic acid; Oxidoreductase
Chromosomal Location of mouse Ortholog: 16 C4|16 54.53 cM
Cellular Component:  cytoplasm; microvillus; subapical complex
Molecular Function:  15-hydroxyprostaglandin dehydrogenase (NADP+) activity; 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity; alcohol dehydrogenase [NAD(P)+] activity; carbonyl reductase (NADPH) activity; oxidoreductase activity; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; prostaglandin-E2 9-reductase activity
Biological Process:  glucocorticoid metabolic process; lipid metabolic process; positive regulation of reactive oxygen species metabolic process; vitamin K metabolic process; xenobiotic metabolic process
Reference #:  P48758 (UniProtKB)
Alt. Names/Synonyms: 15-hydroxyprostaglandin dehydrogenase; 15-hydroxyprostaglandin dehydrogenase [NADP(+)]; 15-hydroxyprostaglandin dehydrogenase [NADP+]; 20-beta-hydroxysteroid dehydrogenase; AW261796; carbonyl reductase 1; Carbonyl reductase [NADPH] 1; Carbonyl reductase [NADPH] 1 (NADPH-dependent carbonyl reductase 1); Cbr; Cbr1; CR; NADPH-dependent carbonyl reductase 1; OTTMUSP00000021476; PG-9-KR; Prostaglandin 9-ketoreductase; Prostaglandin-E(2) 9-reductase
Gene Symbols: Cbr1
Molecular weight: 30,641 Da
Basal Isoelectric point: 8.53  Predict pI for various phosphorylation states
Select Structure to View Below

CBR1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein