COL4A2 Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins. Belongs to the type IV collagen family. Note: This description may include information from UniProtKB.
Protein type: Extracellular matrix; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 8 A1.1|8 5.62 cM
Cellular Component:  basement membrane; collagen trimer; collagen type IV trimer; extracellular matrix; extracellular region; extracellular space
Molecular Function:  extracellular matrix structural constituent; extracellular matrix structural constituent conferring tensile strength
Biological Process:  angiogenesis; cellular response to transforming growth factor beta stimulus; collagen-activated tyrosine kinase receptor signaling pathway; extracellular matrix organization; negative regulation of angiogenesis; transcription, DNA-templated
Reference #:  P08122 (UniProtKB)
Alt. Names/Synonyms: AU019502; Canstatin; CO4A2; Col4; Col4a-2; Col4a2; Collagen alpha-2(IV) chain; collagen, type IV, alpha 2; MGC7371; OTTMUSP00000023606; procollagen, type IV, alpha 2
Gene Symbols: Col4a2
Molecular weight: 167,325 Da
Basal Isoelectric point: 8.75  Predict pI for various phosphorylation states
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COL4A2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene