|
COL4A2
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins. Belongs to the type IV collagen family. Note: This description may include information from UniProtKB.
|
| Protein type: Extracellular matrix; Secreted; Secreted, signal peptide |
| Chromosomal Location of Human Ortholog: 8 A1.1|8 5.62 cM |
|
Cellular Component:
basement membrane; collagen trimer; collagen type IV trimer; extracellular matrix; extracellular region; extracellular space
|
|
Molecular Function:
extracellular matrix structural constituent; extracellular matrix structural constituent conferring tensile strength
|
|
Biological Process:
angiogenesis; cellular response to transforming growth factor beta stimulus; collagen-activated tyrosine kinase receptor signaling pathway; extracellular matrix organization; negative regulation of angiogenesis; transcription, DNA-templated
|
|
Reference #:
P08122
(UniProtKB)
|
|
Alt. Names/Synonyms: AU019502; Canstatin; CO4A2; Col4; Col4a-2; Col4a2; Collagen alpha-2(IV) chain; collagen, type IV, alpha 2; MGC7371; OTTMUSP00000023606; procollagen, type IV, alpha 2
|
|
Gene Symbols: Col4a2
|
|
Molecular weight:
167,325 Da
|
|
Basal Isoelectric point:
8.75
Predict pI for various phosphorylation states
|
