COL4A2
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins. Belongs to the type IV collagen family. Note: This description may include information from UniProtKB.
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Protein type: Extracellular matrix; Secreted; Secreted, signal peptide |
Chromosomal Location of human Ortholog: 13q34 |
Cellular Component:
basement membrane; collagen type IV trimer; collagen-containing extracellular matrix; endoplasmic reticulum lumen; extracellular region; extracellular space
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Molecular Function:
extracellular matrix structural constituent; extracellular matrix structural constituent conferring tensile strength; protein binding
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Biological Process:
angiogenesis; cellular response to transforming growth factor beta stimulus; collagen-activated tyrosine kinase receptor signaling pathway; DNA-templated transcription; endodermal cell differentiation; extracellular matrix organization; negative regulation of angiogenesis; response to activity
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Disease: Hemorrhage, Intracerebral, Susceptibility To; Porencephaly 2
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Reference #:
P08572
(UniProtKB)
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Alt. Names/Synonyms: BSVD2; Canstatin; CO4A2; COL4A2; Collagen alpha-2(IV) chain; collagen type IV alpha 2 chain; collagen, type IV, alpha 2; DKFZp686I14213; FLJ22259; ICH; POREN2
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Gene Symbols: COL4A2
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Molecular weight:
167,553 Da
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Basal Isoelectric point:
8.89
Predict pI for various phosphorylation states
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