COL4A2 Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins. Belongs to the type IV collagen family. Note: This description may include information from UniProtKB.
Protein type: Extracellular matrix; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 13q34
Cellular Component:  collagen type IV trimer; endoplasmic reticulum lumen; extracellular region
Molecular Function:  extracellular matrix structural constituent; extracellular matrix structural constituent conferring tensile strength; protein binding
Biological Process:  aging; angiogenesis; cellular response to transforming growth factor beta stimulus; endodermal cell differentiation; extracellular matrix organization; negative regulation of angiogenesis; response to activity; transcription, DNA-templated
Disease: Hemorrhage, Intracerebral, Susceptibility To; Porencephaly 2
Reference #:  P08572 (UniProtKB)
Alt. Names/Synonyms: BSVD2; Canstatin; CO4A2; COL4A2; Collagen alpha-2(IV) chain; collagen type IV alpha 2 chain; collagen, type IV, alpha 2; DKFZp686I14213; FLJ22259; ICH; POREN2
Gene Symbols: COL4A2
Molecular weight: 167,553 Da
Basal Isoelectric point: 8.89  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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