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CA2
Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. Belongs to the alpha-carbonic anhydrase family. Note: This description may include information from UniProtKB.
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| Protein type: EC 4.2.1.1; Energy Metabolism - nitrogen; Lyase |
| Chromosomal Location of mouse Ortholog: 3 A1|3 3.23 cM |
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Cellular Component:
apical part of cell; axon; basolateral plasma membrane; cytoplasm; cytosol; extracellular space; membrane; microvillus; myelin sheath; plasma membrane
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Molecular Function:
arylesterase activity; carbonate dehydratase activity; lyase activity; metal ion binding; protein binding; zinc ion binding
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Biological Process:
angiotensin-activated signaling pathway; carbon dioxide transport; morphogenesis of an epithelium; neuron cellular homeostasis; one-carbon metabolic process; positive regulation of bone resorption; positive regulation of cellular pH reduction; positive regulation of dipeptide transmembrane transport; positive regulation of osteoclast differentiation; positive regulation of synaptic transmission, GABAergic; regulation of chloride transport; regulation of intracellular pH; regulation of monoatomic anion transport; regulation of pH; secretion
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Reference #:
P00920
(UniProtKB)
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Alt. Names/Synonyms: AI131712; CA II; CA-II; Ca2; CAH2; CAII; Car; Car-2; Car2; Carbonate dehydratase II; Carbonic anhydrase 2; Carbonic anhydrase II; Ltw-; Ltw-5; Lvtw; Lvtw-5
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Gene Symbols: Car2
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Molecular weight:
29,033 Da
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Basal Isoelectric point:
6.49
Predict pI for various phosphorylation states
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