RMP Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein. Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination. Belongs to the RNA polymerase II subunit 5-mediating protein family. Ubiquitous. Expressed in ovarian cancers (at protein level). Expressed strongly in skeletal muscle. Expressed weakly in brain, heart, pancreas and in prostate epithelial cells. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 19q12
Cellular Component:  cytoplasm; cytosol; dendrite; mitochondrion; nucleoplasm; nucleus
Molecular Function:  chromatin binding; phosphoprotein binding; protein binding; protein phosphatase inhibitor activity; RNA polymerase II complex binding; transcription corepressor activity
Biological Process:  cellular response to growth factor stimulus; cellular response to steroid hormone stimulus; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of phosphatase activity; negative regulation of phosphoprotein phosphatase activity; negative regulation of transcription by RNA polymerase II; regulation of cell growth; regulation of transcription by RNA polymerase II; response to virus
Reference #:  O94763 (UniProtKB)
Alt. Names/Synonyms: C19orf2; chromosome 19 open reading frame 2; FLJ10575; NNX3; PPP1R19; Protein NNX3; Protein phosphatase 1 regulatory subunit 19; protein phosphatase 1, regulatory subunit 19; RMP; RNA polymerase II subunit 5-mediating protein; RNA polymerase II, subunit 5-mediating protein; RPB5-mediating protein; Unconventional prefoldin RPB5 interactor; Unconventional prefoldin RPB5 interactor 1; URI; URI1; URI1 prefoldin like chaperone
Gene Symbols: URI1
Molecular weight: 59,832 Da
Basal Isoelectric point: 4.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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RMP

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein