DGKI Belongs to the eukaryotic diacylglycerol kinase family. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q33
Cellular Component:  axon terminus; cytoplasm; cytosol; dendritic spine; excitatory synapse; extrinsic component of postsynaptic density membrane; extrinsic component of presynaptic active zone membrane; glutamatergic synapse; guanyl-nucleotide exchange factor complex; neuronal cell body; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; protein-containing complex; Schaffer collateral - CA1 synapse; synapse; synaptic vesicle
Molecular Function:  ATP binding; diacylglycerol kinase activity; GTPase inhibitor activity; metal ion binding; NAD+ kinase activity; protein binding; Ras GTPase binding
Biological Process:  excitatory postsynaptic potential; habituation; lipid phosphorylation; negative regulation of GTPase activity; neurotransmitter secretion; platelet activation; positive regulation of Ras protein signal transduction; protein kinase C-activating G protein-coupled receptor signaling pathway; regulation of long-term synaptic depression; regulation of synaptic vesicle exocytosis
Reference #:  O75912 (UniProtKB)
Alt. Names/Synonyms: DAG kinase iota; DGK-iota; DGKI; Diacylglycerol kinase iota; diacylglycerol kinase, iota; Diglyceride kinase iota
Gene Symbols: DGKI
Molecular weight: 116,997 Da
Basal Isoelectric point: 7.98  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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