PLA2G6 Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods. Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity. Four different transcripts were found to be expressed in a distinct tissue distribution. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase
Chromosomal Location of Human Ortholog: 15|15 E1
Cellular Component:  cytoplasm; cytosol; extracellular space; membrane; microtubule organizing center; mitochondrion
Molecular Function:  ATP-dependent protein binding; calcium-independent phospholipase A2 activity; calmodulin binding; hydrolase activity; phospholipase A2 activity; protein kinase binding; serine hydrolase activity
Biological Process:  antibacterial humoral response; cardiolipin biosynthetic process; chemotaxis; lipid catabolic process; lipid metabolic process; memory; negative regulation of synaptic transmission, glutamatergic; positive regulation of arachidonic acid secretion; positive regulation of blood vessel diameter; positive regulation of ceramide biosynthetic process; positive regulation of cytosolic calcium ion concentration; positive regulation of exocytosis; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of protein kinase C signaling; positive regulation of protein phosphorylation; positive regulation of release of cytochrome c from mitochondria; regulation of store-operated calcium channel activity; response to endoplasmic reticulum stress; urinary bladder smooth muscle contraction
Reference #:  P97819 (UniProtKB)
Alt. Names/Synonyms: 85 kDa calcium-independent phospholipase A2; 85/88 kDa calcium-independent phospholipase A2; BB112799; CaI-PLA2; Group VI phospholipase A2; GVI PLA2; iPLA(2)beta; iPLA2; iPLA2beta; PA2G6; phospholipase A2, group VI; Pla2g6
Gene Symbols: Pla2g6
Molecular weight: 89,560 Da
Basal Isoelectric point: 6.82  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene