PLA2G6 Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods. Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity. Four different transcripts were found to be expressed in a distinct tissue distribution. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component:  cytosol; extracellular space; membrane; microtubule organizing center; mitochondrion
Molecular Function:  ATP-dependent protein binding; calcium-independent phospholipase A2 activity; calmodulin binding; hydrolase activity; phospholipase A2 activity; phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine); phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine); protein kinase binding; serine hydrolase activity
Biological Process:  antibacterial humoral response; cardiolipin biosynthetic process; chemotaxis; Fc-gamma receptor signaling pathway involved in phagocytosis; lipid catabolic process; maternal process involved in female pregnancy; memory; negative regulation of synaptic transmission, glutamatergic; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; positive regulation of arachidonic acid secretion; positive regulation of blood vessel diameter; positive regulation of ceramide biosynthetic process; positive regulation of cytosolic calcium ion concentration; positive regulation of exocytosis; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of protein kinase C signaling; positive regulation of protein phosphorylation; positive regulation of release of cytochrome c from mitochondria; regulation of store-operated calcium channel activity; response to endoplasmic reticulum stress; urinary bladder smooth muscle contraction
Disease: Neurodegeneration With Brain Iron Accumulation 2a; Neurodegeneration With Brain Iron Accumulation 2b; Parkinson Disease 14, Autosomal Recessive
Reference #:  O60733 (UniProtKB)
Alt. Names/Synonyms: 2-lysophosphatidylcholine acylhydrolase; 85 kDa calcium-independent phospholipase A2; 85/88 kDa calcium-independent phospholipase A2; CaI-PLA2; calcium-independent phospholipase A2; cytosolic, calcium-independent phospholipase A2; Group VI phospholipase A2; GVI; GVI PLA2; INAD1; Intracellular membrane-associated calcium-independent phospholipase A2 beta; IPLA2; iPLA2-beta; IPLA2-VIA; iPLA2beta; NBIA2; NBIA2A; NBIA2B; neurodegeneration with brain iron accumulation 2; PA2G6; Palmitoyl-CoA hydrolase; PARK14; patatin-like phospholipase domain containing 9; Patatin-like phospholipase domain-containing protein 9; phospholipase A2 group VI; phospholipase A2, group VI (cytosolic, calcium-independent); PLA2; PLA2G6; PLPL9; PLPLA9; PNPLA9
Gene Symbols: PLA2G6
Molecular weight: 89,903 Da
Basal Isoelectric point: 6.86  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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