HS6ST1 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid. Belongs to the sulfotransferase 6 family. Expressed in fetal brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.8.2.-; Glycan Metabolism - heparan sulfate biosynthesis; Membrane protein, integral; Transferase
Chromosomal Location of Human Ortholog: 2q14.3
Cellular Component:  Golgi membrane; integral component of plasma membrane
Molecular Function:  sulfotransferase activity
Biological Process:  angiogenesis; glycosaminoglycan biosynthetic process; labyrinthine layer blood vessel development; lung alveolus development; neuron development
Disease: Hypogonadotropic Hypogonadism 15 With Or Without Anosmia
Reference #:  O60243 (UniProtKB)
Alt. Names/Synonyms: DKFZp547H098; FLJ25392; H6ST1; heparan sulfate 6-O-sulfotransferase 1; Heparan-sulfate 6-O-sulfotransferase 1; heparan-sulfate 6-sulfotransferase; HH15; HS6ST; HS6ST-1; HS6ST1; MGC116899; MGC116901
Gene Symbols: HS6ST1
Molecular weight: 48,226 Da
Basal Isoelectric point: 9.04  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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