MLL Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis. Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer. Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. Heart, lung, brain and T- and B-lymphocytes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 9 A5.2|9 24.84 cM
Cellular Component:  cytosol; histone methyltransferase complex; MLL1 complex; nucleoplasm; nucleus
Molecular Function:  chromatin binding; DNA binding; histone methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; identical protein binding; lysine-acetylated histone binding; metal ion binding; methyltransferase activity; protein binding; protein homodimerization activity; RNA polymerase II distal enhancer sequence-specific DNA binding; transcription regulatory region DNA binding; transferase activity; unmethylated CpG binding; zinc ion binding
Biological Process:  anterior/posterior pattern specification; chromatin organization; circadian regulation of gene expression; cognition; definitive hemopoiesis; DNA methylation; embryonic hemopoiesis; exploration behavior; histone H3-K4 dimethylation; histone H3-K4 methylation; histone H3-K4 trimethylation; histone H4-K16 acetylation; homeostasis of number of cells within a tissue; methylation; negative regulation of cell proliferation; negative regulation of DNA methylation; peptidyl-lysine monomethylation; positive regulation of cellular response to drug; positive regulation of histone H3-K4 methylation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of transporter activity; post-embryonic development; protein-containing complex assembly; regulation of gene expression; regulation of histone H3-K14 acetylation; regulation of histone H3-K27 acetylation; regulation of histone H3-K4 methylation; regulation of histone H3-K9 acetylation; regulation of short-term neuronal synaptic plasticity; regulation of transcription, DNA-templated; response to light stimulus; rhythmic process; spleen development; visual learning
Reference #:  P55200 (UniProtKB)
Alt. Names/Synonyms: 6430520K01; ALL-1; All1; C-terminal cleavage product of 180 kDa; Cxxc7; Histone-lysine N-methyltransferase 2A; Histone-lysine N-methyltransferase MLL; Hrx; HTRX; HTRX1; KIAA4050; KMT2A; lysine (K)-specific methyltransferase 2A; Lysine N-methyltransferase 2A; mKIAA4050; Mll; MLL cleavage product C180; MLL cleavage product N320; Mll1; Myeloid/lymphoid or mixed-lineage leukemia; myeloid/lymphoid or mixed-lineage leukemia 1; Myeloid/lymphoid or mixed-lineage leukemia protein 1; N-terminal cleavage product of 320 kDa; p180; p320; trithorax Drosophila; Zinc finger protein HRX
Gene Symbols: Kmt2a
Molecular weight: 429,649 Da
Basal Isoelectric point: 9.29  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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MLL

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene