ZHX2 Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells. In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex. Belongs to the ZHX family. Ubiquitously expressed. Expressed in podocytes. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 8q24.13
Cellular Component:  cytosol; nucleoplasm; nucleus; plasma membrane
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transcription corepressor activity
Biological Process:  mRNA catabolic process; negative regulation of neuron differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; retinal bipolar neuron differentiation; somatic stem cell population maintenance
Reference #:  Q9Y6X8 (UniProtKB)
Alt. Names/Synonyms: AFP regulator 1; AFR1; Alpha-fetoprotein regulator 1; KIAA0854; RAF; Regulator of AFP; transcription factor ZHX2; ZHX2; Zinc finger and homeodomain protein 2; zinc fingers and homeoboxes 2; Zinc fingers and homeoboxes protein 2; zinc-fingers and homeoboxes 2
Gene Symbols: ZHX2
Molecular weight: 92,307 Da
Basal Isoelectric point: 6.42  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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ZHX2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene