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ZHX2
Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells. In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex. Belongs to the ZHX family. Ubiquitously expressed. Expressed in podocytes. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 8q24.13 |
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Cellular Component:
chromatin; cytosol; nucleoplasm; nucleus
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Molecular Function:
DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity
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Biological Process:
mRNA catabolic process; negative regulation of DNA-templated transcription; negative regulation of neuron differentiation; negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; retinal bipolar neuron differentiation; somatic stem cell population maintenance
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Reference #:
Q9Y6X8
(UniProtKB)
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Alt. Names/Synonyms: AFP regulator 1; AFR1; Alpha-fetoprotein regulator 1; KIAA0854; RAF; Regulator of AFP; transcription factor ZHX2; ZHX2; Zinc finger and homeodomain protein 2; zinc fingers and homeoboxes 2; Zinc fingers and homeoboxes protein 2; zinc-fingers and homeoboxes 2
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Gene Symbols: ZHX2
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Molecular weight:
92,307 Da
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Basal Isoelectric point:
6.42
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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