MAEA Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1. Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages. Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis. Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events. Detected at macrophage membranes (at protein level). Ubiquitous. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Cell adhesion; Cell development/differentiation; Membrane protein, integral; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of human Ortholog: 4p16.3
Cellular Component:  actomyosin contractile ring; cytoplasm; cytoskeleton; GID complex; nuclear matrix; nucleoplasm; nucleus; plasma membrane; spindle; ubiquitin ligase complex
Molecular Function:  actin binding; metal ion binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity
Biological Process:  cell adhesion; cell cycle; cell division; cytoskeleton organization; enucleate erythrocyte development; erythrocyte maturation; negative regulation of myeloid cell apoptotic process; proteasome-mediated ubiquitin-dependent protein catabolic process; protein ubiquitination; regulation of mitotic cell cycle
Reference #:  Q7L5Y9 (UniProtKB)
Alt. Names/Synonyms: Cell proliferation-inducing gene 5 protein; E3 ubiquitin-protein transferase MAEA; EMLP; EMP; Erythroblast macrophage protein; GID complex subunit 9, FYV10 homolog; GID9; HLC-10; Human lung cancer oncogene 10 protein; lung cancer-related protein 10; Macrophage erythroblast attacher; macrophage erythroblast attacher, E3 ubiquitin ligase; MAEA; P44EMLP; PIG5; proliferation-inducing gene 5
Gene Symbols: MAEA
Molecular weight: 45,287 Da
Basal Isoelectric point: 8.95  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein