VPS8 Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Functions predominantly in APPL1-containing endosomes. Belongs to the VPS8 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of human Ortholog: 3q27.2
Cellular Component:  early endosome
Molecular Function:  metal ion binding; protein binding
Biological Process:  endosomal vesicle fusion; protein transport
Reference #:  Q8N3P4 (UniProtKB)
Alt. Names/Synonyms: FLJ32099; KIAA0804; vacuolar protein sorting 8 homolog; vacuolar protein sorting 8 homolog (S. cerevisiae); Vacuolar protein sorting-associated protein 8 homolog; VPS8; VPS8 subunit of CORVET complex; VPS8, CORVET complex subunit
Gene Symbols: VPS8
Molecular weight: 161,754 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein