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VPS8
Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Functions predominantly in APPL1-containing endosomes. Belongs to the VPS8 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Ubiquitin conjugating system |
| Chromosomal Location of human Ortholog: 3q27.2 |
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Cellular Component:
early endosome
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Molecular Function:
metal ion binding; protein binding
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Biological Process:
endosomal vesicle fusion; protein transport
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Reference #:
Q8N3P4
(UniProtKB)
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Alt. Names/Synonyms: FLJ32099; KIAA0804; vacuolar protein sorting 8 homolog; vacuolar protein sorting 8 homolog (S. cerevisiae); Vacuolar protein sorting-associated protein 8 homolog; VPS8; VPS8 subunit of CORVET complex; VPS8, CORVET complex subunit
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Gene Symbols: VPS8
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Molecular weight:
161,754 Da
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Basal Isoelectric point:
5.41
Predict pI for various phosphorylation states
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