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KBTBD8
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. Belongs to the KBTBD8 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of human Ortholog: 3p14.1 |
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Cellular Component:
Cul3-RING ubiquitin ligase complex; cytosol; Golgi apparatus; spindle
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Molecular Function:
protein binding
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Biological Process:
neural crest cell development; neural crest formation; protein monoubiquitination; regulation of translation
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Reference #:
Q8NFY9
(UniProtKB)
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Alt. Names/Synonyms: FLJ57592; KBTB8; KBTBD8; kelch repeat and BTB (POZ) domain containing 8; kelch repeat and BTB domain containing 8; Kelch repeat and BTB domain-containing protein 8; KIAA1842; T-cell activation kelch repeat protein; TA-KRP; TAKRP
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Gene Symbols: KBTBD8
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Molecular weight:
68,823 Da
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Basal Isoelectric point:
5.88
Predict pI for various phosphorylation states
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