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CYFIP1
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA. Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. May act as an invasion suppressor in cancers. Belongs to the CYFIP family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of mouse Ortholog: 7|7 B5 |
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Cellular Component:
axonal growth cone; cell projection; central region of growth cone; cytoplasm; dendritic growth cone; dendritic spine; excitatory synapse; filopodium tip; lamellipodium; mRNA cap binding complex; neuron projection; neuronal cell body; perinuclear region of cytoplasm; peripheral region of growth cone; postsynapse; SCAR complex; synapse; terminal bouton
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Molecular Function:
actin binding; profilin binding; protein binding; RNA 7-methylguanosine cap binding; small GTPase binding
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Biological Process:
axon extension; axon guidance; cell differentiation; cell morphogenesis; cellular response to insulin stimulus; cognition; dendrite extension; lamellipodium assembly; modification of synaptic structure; multicellular organism development; negative regulation of synaptic vesicle recycling; nervous system development; neuron projection development; positive regulation of Arp2/3 complex-mediated actin nucleation; positive regulation of axon extension; positive regulation of axonogenesis; positive regulation of dendrite development; positive regulation of lamellipodium assembly; positive regulation of neurotrophin TRK receptor signaling pathway; positive regulation of ruffle assembly; Rac protein signal transduction; regulation of actin filament polymerization; regulation of cell shape; regulation of modification of postsynaptic actin cytoskeleton; regulation of myelination; regulation of translation; regulation of translation at postsynapse, modulating synaptic transmission; response to electrical stimulus
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Reference #:
Q7TMB8
(UniProtKB)
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Alt. Names/Synonyms: Cyfip1; CYFP1; cytoplasmic FMR1 interacting protein 1; Cytoplasmic FMR1-interacting protein 1; E030028J09Rik; Kiaa0068; l(7); l(7)1Rl; l71Rl; l7Rl1; mKIAA0068; P140S; P140SRA-1; P140sra1; pl-1; Shy; Shyc; Specifically Rac1-associated protein 1; Sra-1; Sra1
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Gene Symbols: Cyfip1
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Molecular weight:
145,241 Da
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Basal Isoelectric point:
6.46
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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