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TRMT61A
Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries. Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.1.1.220; Methyltransferase |
| Chromosomal Location of Human Ortholog: 12|12 F1 |
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Cellular Component:
nucleus; tRNA (m1A) methyltransferase complex
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Molecular Function:
methyltransferase activity; mRNA (adenine-N1-)-methyltransferase activity; transferase activity
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Biological Process:
methylation; mRNA methylation; tRNA methylation; tRNA processing
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Reference #:
Q80XC2
(UniProtKB)
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Alt. Names/Synonyms: 6720458F09Rik; AI606093; Gcd14; mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A; Trm61; Trmt61a; tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61; tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61A; tRNA methyltransferase 61 homolog A; tRNA methyltransferase 61 homolog A (S. cerevisiae); tRNA methyltransferase 61A; tRNA(m1A58)-methyltransferase subunit TRM61; tRNA(m1A58)-methyltransferase subunit TRMT61A; tRNA(m1A58)MTase subunit TRM61; tRNA(m1A58)MTase subunit TRMT61A
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Gene Symbols: Trmt61a
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Molecular weight:
31,639 Da
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Basal Isoelectric point:
6.3
Predict pI for various phosphorylation states
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