TRMT61A Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries. Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family. Note: This description may include information from UniProtKB.
Protein type: EC 2.1.1.220; Methyltransferase
Chromosomal Location of Human Ortholog: 12|12 F1
Cellular Component:  nucleus; tRNA (m1A) methyltransferase complex
Molecular Function:  methyltransferase activity; mRNA (adenine-N1-)-methyltransferase activity; transferase activity
Biological Process:  methylation; mRNA methylation; tRNA methylation; tRNA processing
Reference #:  Q80XC2 (UniProtKB)
Alt. Names/Synonyms: 6720458F09Rik; AI606093; Gcd14; mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A; Trm61; Trmt61a; tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61; tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61A; tRNA methyltransferase 61 homolog A; tRNA methyltransferase 61 homolog A (S. cerevisiae); tRNA methyltransferase 61A; tRNA(m1A58)-methyltransferase subunit TRM61; tRNA(m1A58)-methyltransferase subunit TRMT61A; tRNA(m1A58)MTase subunit TRM61; tRNA(m1A58)MTase subunit TRMT61A
Gene Symbols: Trmt61a
Molecular weight: 31,639 Da
Basal Isoelectric point: 6.3  Predict pI for various phosphorylation states
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TRMT61A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene