|
TRMT61A
Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries. Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family. Note: This description may include information from UniProtKB.
|
| Protein type: EC 2.1.1.220; Methyltransferase |
| Chromosomal Location of human Ortholog: 14q32.33 |
|
Cellular Component:
nucleoplasm; nucleus; tRNA (m1A) methyltransferase complex
|
|
Molecular Function:
mRNA (adenine-N1-)-methyltransferase activity; protein binding; tRNA (adenine-N1-)-methyltransferase activity
|
|
Biological Process:
mRNA methylation; tRNA methylation
|
|
Reference #:
Q96FX7
(UniProtKB)
|
|
Alt. Names/Synonyms: C14orf172; FLJ40452; GCD14; Gcd14p; hTRM61; mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A; TRM61; TRMT61A; tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61; tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61A; tRNA methyltransferase 61 homolog A; tRNA methyltransferase 61 homolog A (S. cerevisiae); tRNA methyltransferase 61A; tRNA(m1A58)-methyltransferase subunit TRM61; tRNA(m1A58)-methyltransferase subunit TRMT61A; tRNA(m1A58)MTase subunit TRM61; tRNA(m1A58)MTase subunit TRMT61A
|
|
Gene Symbols: TRMT61A
|
|
Molecular weight:
31,382 Da
|
|
Basal Isoelectric point:
6.89
Predict pI for various phosphorylation states
|
